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What is ONC201?


ONC201 is the latest treatment for cancer cells that have been shown to kill most cancer cells without harming healthy cells in the body. This drug is being tested in a clinical trial for patients with recurrent glioblastoma or WHO Grade IV gliomas with the H3 K27M mutation.

ONC201 is an orally-active small molecule that targets the DRD2 receptor and kills cancer cells. For patients with newly-identified diffuse intrinsic pontine glioma, which is a type of brain cancer, the drug is eligible without histologic confirmation.

ONC201 targets the DRD2 receptor, an overexpressed protein in the brain known to promote the growth of cancer cells. Its goal is to stop the molecular death that can occur when these pathways are disrupted.

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Importance of ONC201

The initial discovery of ONC201 was made based on the activation of the pathway known as the TRAIL. However, in the course of its development, efforts were also made to identify the molecular targets of the drug. These targets were eventually revealed to be related to the class of neurotransmitters known to play a role in cancer development.

Cost of ONC201

ONC201, with all the advanced drug properties, is expensive, and the Average amount people collect during a fundraiser is around €218,750. “Fundraisers” not only gather funds for the treatment but also for the travel expenses, rehabilitation, and for other counseling sessions. In most cases when the patient doesn’t have insurance, they use crowdfunding platforms to cover all the costs of ONC201.


How to start a fundraiser?

Follow these 4 simple steps

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1. Start A Fundraiser
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2. Share Your Fundraiser
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3. Receive The Donations
The donations are paid out automatically to your bank account on a monthly basis without any platform cost.

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4. Thank Your Donors
Customize the automated “Thank You” email or send a personal message to your donors via the WhyDonate dashboard.

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